Chen Daijie: "economic benefits" is the main cause of antibiotic abuse

On June 28, 2012, the 47th New Drug Trade Fair was held in Qingdao. During the conference, Chen Daijie, deputy director of China National Institute of Pharmaceutical Industry, accepted an interview with reporters on antibiotic abuse and domestic new drug research and development.

Antibiotics extend human life to ensure that human health <br> <br> when it comes to abuse of antibiotics, Chen Yuanzhang first said: "Now the community on the issue of bacterial resistance is very concerned about the misuse of antibiotics is also very concerned about the problem, but We hope that we will not go to the other end because of this concern and believe that antibiotics are the culprit. In fact, if we do not have antibiotics, we would not have humans today. The discovery of antibiotics has increased the average life expectancy of our people by more than 15 years. So far we have been in hospitals. Antibiotics are also a key drug in life-saving treatment.

This is what I first explained to you as an expert. Antibiotics are still a good thing. Without antibiotics, humans can't imagine life extension and health guarantees. ”

"Economic Benefits" Are Causes of Abuse of Clinical and Nonclinical Antibiotics <br><br><br><br><br><br><br><br><br> President Chen said: "The widespread abuse of antibiotics is mainly due to the following three aspects related to economic benefits: First, the hospital also There is medicine to support medical practitioners. Hospital doctors prescribe antibiotics and are directly linked to the benefits of their units and individual benefits. According to statistics, in 2010, China's average use of antibiotics was 138g, which is about 10 times that of the global average. Our national antibiotics In the total amount of therapeutic drugs, it accounts for more than one-third of the total, and the number of antibiotics used in clinical medicine was more than 80,000 tons in 2010. Second, people’s demand for poultry, fish, shrimp, and meat products is increasing. Therefore, antibiotics are used as animal husbandry. The feed additive used in the study promotes the growth of animals and the prevention of animal infections, and uses a large amount of antibiotics. The non-clinical use of antibiotics in China reached 97,000 tons in 2010. Third, wastes containing antibiotics from antibiotic production companies and hospitals are released to the environment. According to estimates, in the general antibiotic production process, about 5%-6% is difficult Extracted from the raw materials, these large amounts of antibiotics that remain in the waste are often released to the environment without complete destruction; in 2010, China produced a total of 210,000 tons of antibiotics. In addition, the lack of public knowledge is also The abuse of clinical antibiotics has played a role in fueling the rise. Our common people have a kind of mentality. To the hospital there is a little fever, a little cold, and a little inflammation that requires the use of antibiotics.

In response to the grim situation in the development of bacterial resistance in China, the state has issued a series of stringent policies on the control of hospitals for the use of drugs to raise medical care and the use of antibiotics; the use of veterinary antibiotics by the state and antibiotics A series of policies have also been introduced in the waste disposal of production companies, and new technologies and methods are applied to prevent the release of large amounts of residual antibiotics to the environment. We believe that with the introduction of “multi-pronged” policies and regulations by the state and the improvement of public scientific knowledge, the abuse of antibiotics will return to a rational state; and as the awareness of environmental protection increases, bacterial resistance in China will increase. The threat of sexual development will be effectively controlled.

Antibiotic abuse is the "culprit" for the development of bacterial resistance

Dean Chen said: The abuse of antibiotics is the “culprit” that causes the development of bacterial drug resistance mainly in the following three aspects. First, the use of antimicrobial agents as a selective pressure kills some sensitive bacteria, destroys a normal animal body, or the microecological environment of the human body's flora, so that individual drug-resistant bacteria can multiply indefinitely. The main reason currently considered to be common. The second is that many antibiotics have an effect of inducing resistance to bacteria, that is, these resistant genes are already present in bacteria, but under normal circumstances, this gene is silent and not expressed; once the antibiotic is abused, These silent drug-resistant genes are expressed and show resistance to antibiotics. The third is that we use a lot of antibiotics. On the one hand, even if we kill the resistant bacteria, it may not have damaged the genetic material that encodes the drug resistance gene. On the other hand, due to the use of a large number of antibiotics, the normal bacterial cells in the body are used. It is sensitive to the absorption of foreign genetic material, so this genetic material is also easily absorbed by normal susceptible bacteria and become resistant bacteria.

In addition, the development of drug-resistant bacteria caused by the abuse of antibiotics can be transmitted through the environment, animals, plants and humans. Some studies have reported that the isolated resistant bacteria in the livestock keepers of a breeding turkey factory in Europe are completely consistent with the resistant bacteria isolated from the feces of turkeys. From this point, it can be proved that drug-resistant bacteria will be transmitted from animals. To humans.

The most important task of drug companies at this stage is to do "imitation drugs"

Talking about the issue of drug innovation research, Dean Chen said: Innovation is the soul of a nation that has established itself as an invincible place, and it is the eternal theme of a country's enterprise. Our country is a big pharmaceutical country, not a powerful country. Innovative drugs are an important leap forward for a big pharmaceutical country to become a pharmaceutical power. Our pharmaceutical companies must truly assume the mission of a strong nation. However, we should also soberly realize that at this stage or in a longer stage, not only our country, but also all countries in the world, it is difficult for innovative drugs to solve the problem of 'difficulties in medication' and 'used drugs' in every country. The problem.

It is really necessary to solve the problems that the people are currently taking expensive drugs and difficult to use good medicine. The most important thing is to do a good job of imitation drugs. In particular, major imitations of drugs and imminent localization of imitations are needed, and they have international competitive advantages in terms of product quality, manufacturing costs, and environmental protection. In this way, we can not only meet the people's demand for medicines in a timely manner, but also can force import products to lower prices or even recapture the domestic market, reducing dependence on foreign medicines.