Release date: 2016-03-17
- If you accidentally take a bite out of a poisonous snake, there are many medicines that can save lives. However, different types of snakes require different medications, and they need to be stored in the refrigerator when they are used. This means that no matter where you are, you must prepare adequate medicine for treatment.
But this situation is likely to be changed, and American scientists say they are developing a spectral antidote to snake bites. The drug is said to be effective in treating 28 different types of common venoms and can be used without medical guidance.
The limitation of developing antidote to snake bites is that there are many different fatal methods for venom secreted by snakes. Including paralysis, tissue damage, vascular blockage or a combination of the three. In order to be effective, detoxification drugs need to have multiple anti-toxic activities at the same time.
At the beginning of the study, Matt Lewin, a Principal Investigator from the California Academy of Sciences, focused on a class of enzymes called SPLA2, which is found in snake venom and also in the body's validation reaction.
The researchers collected various compounds found in clinical treatment that bind to sPLA2, after which they mixed different toxins with the above compounds and used indicators to measure the level of sPLA2 in the samples. One of the compounds, varespladib (which was originally developed to treat wound infections), stands out:
Lewin collaborated with researchers at Yale University to test the response of the compound to 28 common venoms. The results showed that the drug was effective in inhibiting the activity of sPLA2 in all venoms.
This result was repeatedly verified in rat trials: a dose of varespladib reduced the activity of sPLA2 in venom and ultimately prevented the risk of death due to snake bites.
This result sounds very happy, but the results have not been officially published. Although the article is still in the writing stage, the initial results are indeed satisfactory.
As an emergency doctor, Lewin hopes to develop a drug to treat snake bites. If successful, 10,000 people die each year from being bitten by a snake bite.
He has now applied for patent protection (ie, applied patent protection) for this product. In other words, without his permission, others must not change the specifications of the drug, the way it is administered, and the purpose of the treatment.
With financial support from family, friends and other developers, Lewin hopes to conduct a related clinical trial.
Source: Bio Valley
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