Pharmacological effects
1. Anti-platelet aggregation function: Experiments have shown that S. aggregata has an antithrombotic effect, and is prepared by dissolving 10 mg each of 10 mg with 0.1 ml of ethanol and adding 1% CMC-Na 0.9 ml as a suspension. The control group is drug-free ethanol and CMC. -Na mixture. A healthy rabbit (body weight 1.9 ± 0.4 kg) was used as a test. The results are as follows:
Effect on extracorporeal thrombosis: 1.8 ml of blood collected from rabbit central arteries was mixed with 0.2 ml of drug solution or control solution, injected into a polyethylene tube ring, and a rotating ring was activated to allow the blood to rotate at 17/r/min at 37°C. minute. A thrombus was poured from the ring, and the length and wet weight of the thrombus were immediately measured. The thrombus was then dried by a thermostat at 20° C. for 20 minutes, and the dry weight of the thrombus was weighed. Results Control group: thrombus length 7.6±2.3cm, thrombus wet weight 202.4±48.1mg, thrombus dry weight 105.6±21.4mg; Suhexiang group: thrombus length 3.7±0.4cm, thrombus wet weight 116.2±20.7cm, thrombus dry weight 55.7± 14.1mg. Compared with the control group, glucomberin 1 mg/ml significantly inhibited thrombosis in vitro.
Effects on cAMP content in platelets: determination of cAMP content in platelets. Results The control group was 7.4±2.8 pmol/mg protein, Suhexiang high dose 2mg/ml was 14.7±4.1pmol/mg protein, and low dose 1mg/ml was 7.5±3.1pmol/mg protein. Compared with the control group, Suhexiang large dose group can significantly increase the platelet cAMP content (P <0.001).
Effect on coagulation:
(1) In vitro experiments: Determination of recalcification time and prothrombin time, partial thromboplastin time and plasmin activity of kaolin. Suhexiang can significantly prolong plasma recalcification time, prothrombin time and kaolin thromboplastin time, and significantly increase plasmin activity.
(2) In vivo experiments: rabbits were intragastrically administered with 100 mg/kg of benzoate and the volume was 10 ml. The control group was given a mixture of equal volume of ethanol and CMC-Na, and physiological saline was used as a blank control. Blood samples were taken before and at different times after administration for the following measurements. The results showed that oral administration of Su Hexiang can significantly prolong recalcification time, prothrombin time and partial thromboplastin time of kaolin, reduce plasma fibrin content, and promote plasmin activity. The main component of anti-platelet aggregation of Su Hexiang is cis-cinnamic acid.
2. Effect on cardiovascular: Guanxin Suhe Pill can significantly increase coronary sinus blood flow in dogs with experimental myocardial infarction, make it normal or nearly normal, and can significantly slow down heart rate and reduce myocardial oxygen consumption; Non-myocardial infarction with large coronary sinus flow has no significant effect, but it can slow down heart rate and reduce myocardial oxygen consumption. Disassembly studies have shown that Guanxin Suhe Pills only have the above-mentioned effects in the combination of Sulfoxylate and Borneol, and the other herbs are ineffective. The Su Bing Dripping Pills, which are composed of Suhexiang and Borneol, have significant anti-ischemic effect, and have obvious protective effects on ischemic ultrastructural changes in mice induced by swimming stress and pituitrin. It can counteract the decrease of the nutritive blood-solubility of the myocardium caused by pituitrin and counteract the contraction of aorta caused by norepinephrine.
3, antibacterial, anti-inflammatory effects: Suhexiang has a weak antibacterial effect, can be used for a variety of respiratory infections. Suhexiang also has a mild stimulatory effect that can be used locally to relieve inflammation, such as eczema and itching, and to promote the healing of ulcers and wounds.
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