Two scientifically grounded papers from researchers at the University of California, Santa Barbara (UCSB) show that nano-sized bioparticle synthesis has the potential to fight cancer and treat other diseases. Two research papers present a new approach to “green†nanotechnology. The reason why it is promoted as "green" is because the new method does not use artificial compounds.
LucJaeger, an associate professor at the University of California, Santa Barbara, explained that there is also a revolution in his field of research; and this is a revolution in all areas of biochemistry, and his nanotechnology field is particularly strong. This revolution is closely related to the understanding of the role of RNA in cells.
Jaeger said: "Considering the fact that as many as 90% of the human genome has been translated into RNA, it is clear that RNA is one of the important biopolymers of Zui that form the basis of life. The significance of RNA is huge, and we are now The full understanding of the significance of RNA in living cells is still far away."
Jaeger's team is working on a complex three-dimensional RNA molecule (a nano-sized polyhedron that can be used to fight disease) that can be used to fight disease-resistant nano-sized polyhedra. These molecules combine themselves into new forms. This work was funded by the National Institutes of Health (NIH), and NIH and UCSB are jointly applying for a patent in relation to the new design.
"We are interested in using RNA combinations to deliver silencing RNAs and therapeutic RNA aptamers to fight cancer and other diseases," he said. "It is clear that RNA is involved in a number of key processes involving health issues."
He believes that new treatments based on RNA-based methods are safer than treatments with artificial compounds, which inevitably have unpleasant side effects.
“With RNA molecules as the main mediator, we are putting 'green' nanotechnology into practice. The research project developed in my UCSB lab aims to make a positive contribution to medicine and synthetic biology. We are trying to make a positive contribution. Avoid using any method that may trigger public controversy about bioethics. This is not an easy task, but I am convinced that in the long run, the benefits outweigh the disadvantages."
The new part of the two scientific papers describes the new work - "Invitroassembly of cubic RNA-based scaffoldsdesigned insilicon" (Nanostructured Silicon Biodegradable - Translator) - August Published on the 30th online in NatureNanotechnology. (Nature - Nanotechnology). An earlier paper, "The Polyhedron Made with tRNA," by Severcan and colleagues, was published online July 18th in NatureChemistry. The printed version of this paper will appear in the September issue of NatureChemistry.
The second author of this "NatureChemistry" paper is a postdoctoral researcher at Jaeger Labs, and KirillA.Afonin, a postdoctoral researcher at the lab, is the author of the paper in NatureNanotechnnology; Bruce Shapiro, one of the co-authors The National Cancer Institute from Friedrich, Maryland, also received financial support from NIH. Jaeger and his team worked with Shapiro to develop a computerized approach that accelerated the design of self-assembled RNA strands. The National Automated Molecular Microscopy Resource Center in La Jolla, Calif., provides further assistance.
LucJaeger, an associate professor at the University of California, Santa Barbara, explained that there is also a revolution in his field of research; and this is a revolution in all areas of biochemistry, and his nanotechnology field is particularly strong. This revolution is closely related to the understanding of the role of RNA in cells.
Jaeger said: "Considering the fact that as many as 90% of the human genome has been translated into RNA, it is clear that RNA is one of the important biopolymers of Zui that form the basis of life. The significance of RNA is huge, and we are now The full understanding of the significance of RNA in living cells is still far away."
Jaeger's team is working on a complex three-dimensional RNA molecule (a nano-sized polyhedron that can be used to fight disease) that can be used to fight disease-resistant nano-sized polyhedra. These molecules combine themselves into new forms. This work was funded by the National Institutes of Health (NIH), and NIH and UCSB are jointly applying for a patent in relation to the new design.
"We are interested in using RNA combinations to deliver silencing RNAs and therapeutic RNA aptamers to fight cancer and other diseases," he said. "It is clear that RNA is involved in a number of key processes involving health issues."
He believes that new treatments based on RNA-based methods are safer than treatments with artificial compounds, which inevitably have unpleasant side effects.
“With RNA molecules as the main mediator, we are putting 'green' nanotechnology into practice. The research project developed in my UCSB lab aims to make a positive contribution to medicine and synthetic biology. We are trying to make a positive contribution. Avoid using any method that may trigger public controversy about bioethics. This is not an easy task, but I am convinced that in the long run, the benefits outweigh the disadvantages."
The new part of the two scientific papers describes the new work - "Invitroassembly of cubic RNA-based scaffoldsdesigned insilicon" (Nanostructured Silicon Biodegradable - Translator) - August Published on the 30th online in NatureNanotechnology. (Nature - Nanotechnology). An earlier paper, "The Polyhedron Made with tRNA," by Severcan and colleagues, was published online July 18th in NatureChemistry. The printed version of this paper will appear in the September issue of NatureChemistry.
The second author of this "NatureChemistry" paper is a postdoctoral researcher at Jaeger Labs, and KirillA.Afonin, a postdoctoral researcher at the lab, is the author of the paper in NatureNanotechnnology; Bruce Shapiro, one of the co-authors The National Cancer Institute from Friedrich, Maryland, also received financial support from NIH. Jaeger and his team worked with Shapiro to develop a computerized approach that accelerated the design of self-assembled RNA strands. The National Automated Molecular Microscopy Resource Center in La Jolla, Calif., provides further assistance.
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