[ China Pharmaceutical Network Technology News ] The molecular machine built by scientists at the University of Alberta has been able to run smoothly in cancer cells. It is reported that every molecular machine does not start until the specially designed receiving device receives the correct signal, these molecular machines will operate, these signal is the cancer-related microRNA (miRNA), that is Molecular machines specifically recognize microRNAs that are characteristic of cancer cells.
This result suggests that molecular machinery is initiated by specific intracellular targets—specific miRNAs within cancer cells—and the results open up new avenues for scientists to develop diverse diagnostic and drug delivery systems.
The nanoscale molecular machine consists of a compartment consisting of a DNase molecule and a substrate. According to its builder, a complete molecular machine has the required fuel, DNA orbitals and molecular switches. Further details regarding the molecular machine can be found in an article by Nature Communications, entitled "A MicroRNA-Initiated DNAzyme Motor Operating in Living Cells", published March 6th.
The author of the article wrote: "The whole machine system is built on a 20 nm diameter particle (AuNP), decorated with hundreds of substrate chains as DNA orbitals and dozens of DNase molecules. Target molecules and machine systems are in the cell. The interaction drives its autonomous walk on the AuNP.
In the current study, the researchers adjusted this nanoscale molecular machine to detect specific miRNA sequences found in breast cancer cells. When it comes into contact with the target molecule, the molecular switch of the system opens and produces fluorescence as part of the reaction. Researchers can monitor fluorescence to detect which cells are cancer cells and determine the location of cancer cells.
Dr. Chris Le pointed out: "We hope that before the patient's condition is out of control, the cancer can be detected by a very small number of disease markers, and trace disease markers not previously detected by the technology can be detected in this technique."
In addition to improving the ability to diagnose diseases, the researchers assert that this molecular machine can also be used for targeted drug delivery to patients. Conventional targeted drug therapy delivers the drug to the site of targeting, but it still affects normal tissues or cells. The team said that with the help of molecular machines, the drug can be delivered accurately and then only when the disease-specific molecule triggers.
"There are some drug molecules that attack normal cells, which is inevitable," Dr. Le said. "Using molecular machines to transport drugs, we can deliver drugs to cells in an inactive form, and only when the molecular machine encounters a targeting molecule can the drug be released.
Although the research team has conducted research on breast cancer markers, the current goal is to examine a wider range of other disease markers. This requires further testing of the nanomachine to better understand its ability to deliver drugs.
Reference materials:
DNA Motors in Living Cells Start with MicroRNA Keys
(Scientists construct new nanomachines for stable drug delivery in cancer cells. Source: Baidu Pictures)
This result suggests that molecular machinery is initiated by specific intracellular targets—specific miRNAs within cancer cells—and the results open up new avenues for scientists to develop diverse diagnostic and drug delivery systems.
The nanoscale molecular machine consists of a compartment consisting of a DNase molecule and a substrate. According to its builder, a complete molecular machine has the required fuel, DNA orbitals and molecular switches. Further details regarding the molecular machine can be found in an article by Nature Communications, entitled "A MicroRNA-Initiated DNAzyme Motor Operating in Living Cells", published March 6th.
The author of the article wrote: "The whole machine system is built on a 20 nm diameter particle (AuNP), decorated with hundreds of substrate chains as DNA orbitals and dozens of DNase molecules. Target molecules and machine systems are in the cell. The interaction drives its autonomous walk on the AuNP.
In the current study, the researchers adjusted this nanoscale molecular machine to detect specific miRNA sequences found in breast cancer cells. When it comes into contact with the target molecule, the molecular switch of the system opens and produces fluorescence as part of the reaction. Researchers can monitor fluorescence to detect which cells are cancer cells and determine the location of cancer cells.
Dr. Chris Le pointed out: "We hope that before the patient's condition is out of control, the cancer can be detected by a very small number of disease markers, and trace disease markers not previously detected by the technology can be detected in this technique."
In addition to improving the ability to diagnose diseases, the researchers assert that this molecular machine can also be used for targeted drug delivery to patients. Conventional targeted drug therapy delivers the drug to the site of targeting, but it still affects normal tissues or cells. The team said that with the help of molecular machines, the drug can be delivered accurately and then only when the disease-specific molecule triggers.
"There are some drug molecules that attack normal cells, which is inevitable," Dr. Le said. "Using molecular machines to transport drugs, we can deliver drugs to cells in an inactive form, and only when the molecular machine encounters a targeting molecule can the drug be released.
Although the research team has conducted research on breast cancer markers, the current goal is to examine a wider range of other disease markers. This requires further testing of the nanomachine to better understand its ability to deliver drugs.
Reference materials:
DNA Motors in Living Cells Start with MicroRNA Keys
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