Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material

Model NO.: CAS: 13647-35-3
Trademark: ZK
Transport Package: Specail and Safely Hidden Pack
Specification: USP
Origin: China
Model NO.: CAS: 13647-35-3
Trademark: ZK
Transport Package: Specail and Safely Hidden Pack
Specification: USP
Origin: China
Quick detail: 
Trilostane
CAS :13647-35-3
Synonym: Vetoryl
Molecular Formula:C20H27NO3
Molecular Weight:329.4333
Einecs No:237-133-0
Appearance:: White crystalline powder
Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.
Trilostane 
 
Description:
Trilostane is an inhibitor of isoforms 3-HSD and 3-HSD2 of the enzyme 3-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3-HSD versus Pro195 in 3-HSD2 attributes to the competitive inhibition of 3-HSD, but not 3-HSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular production oin LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.
 
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material

COA:
Test  Item Analysis  Specification Result
Description White to off-white power Conforms
Purity 98.5%min 99.20%
Water(K.F) ≤0.5% 0.20%
Loss on drying ≤0.5% 0.26%
Residue on ignition ≤0.1% 0.04%
Heavy metals ≤20ppm <20ppm
Specific optional rotation +137°~ +139° +138.8°

 
Applications:
Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
 
Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.
 
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
 
Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
 
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material

Product list:
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material


 
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material

Our advantages: 
1. Top quality and factory price,a discount would be given when you make a large order.
2. Rich experienced in delivering,package will be reshipped if sent failed. 
3. Enough stock ensure the prompt delivery time. 
4. Good after-sales service,any of your question would be solved for the first as soon as possible.
5. Adhering to the principle of customer first conviction,we will provide the best and the most sincere services as possible as we can. 
  Quick detail: 
Trilostane
CAS :13647-35-3
Synonym: Vetoryl
Molecular Formula:C20H27NO3
Molecular Weight:329.4333
Einecs No:237-133-0
Appearance:: White crystalline powder
Usage : Trilostane can inhibit cortical hormone in the process of synthesis of 3 beta dehydrogenase, make the cortisol, aldosterone synthesis decreased, clinically used in the treatment of Cushing syndrome (hypercortisolism) and primary aldosteronism. This product also had significantly effect to decreased serum testosterone level.
Trilostane 
 
Description:
Trilostane is an inhibitor of isoforms 3-HSD and 3-HSD2 of the enzyme 3-hydroxysteroid dehydrogenase, which plays a role in adrenal steroid biosynthesis. Investigators believe that Arg195 in 3-HSD versus Pro195 in 3-HSD2 attributes to the competitive inhibition of 3-HSD, but not 3-HSD2 by Trilostane. Research shows that trilostane is effective in suppressing the intracellular production oin LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis in the human adrenal gland. This product serves as a useful tool in steroid biosynthesis research.
 
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material

COA:
Test  Item Analysis  Specification Result
Description White to off-white power Conforms
Purity 98.5%min 99.20%
Water(K.F) ≤0.5% 0.20%
Loss on drying ≤0.5% 0.26%
Residue on ignition ≤0.1% 0.04%
Heavy metals ≤20ppm <20ppm
Specific optional rotation +137°~ +139° +138.8°

 
Applications:
Trilostane is used in the treatment of Cushing's syndrome. It is normally used in short-term treatment until permanent therapy is possible.
 
Trilostane blocks an enzyme involved in the production of several steroids including cortisol. Inhibiting this enzyme inhibits the production of cortisol. In Cushing's syndrome, the adrenal gland overproduces steroids. Although steroids are important for various functions of the body, too much can cause problems. Trilostane reduces the amount of steroids produced by the adrenal gland.
 
Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.
 
Side effect:Symptoms of overdose include darkening of skin, drowsiness or tiredness, loss of appetite, mental depression, skin rash, and/or vomiting.
 
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material

Product list:
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material


 
Anti Estrogen Breast Cancer Vetoryl Powder Trilostane Pharmaceutical Raw Material

Our advantages: 
1. Top quality and factory price,a discount would be given when you make a large order.
2. Rich experienced in delivering,package will be reshipped if sent failed. 
3. Enough stock ensure the prompt delivery time. 
4. Good after-sales service,any of your question would be solved for the first as soon as possible.
5. Adhering to the principle of customer first conviction,we will provide the best and the most sincere services as possible as we can. 
 

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