Chinese scientists have made important breakthroughs in the research of tumor photodynamic therapy
August 31, 2018 Source: Ministry of Science and Technology
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Resistance is the leading cause of chemotherapy failure in cancer patients and a major challenge in cancer. Photodynamic therapy (PDT) can use photo-excited photosensitizers such as porphyrin to produce reactive oxygen species to kill tumor cells. It has less trauma, less toxicity, faster recovery, protects appearance, and can detect early cancer by photodynamic fluorescence diagnosis. Precancerous lesions are non-invasive, rapid, and objective. However, after a single photodynamic treatment, the tumor is prone to recurrence.
Under the support of the National Key Research and Development Program Nanotechnology Key Project “Nano-molecular Imaging Probe-based Cancer Minimally Invasive Interventional Navigation Technologyâ€, Professor Dai Zhifei from Peking University School of Engineering collaborated with Peking University Third Hospital to design and synthesize amphipathic Porphyrin lipid and camptothecin-fluorouridine drug conjugate, and as a film-forming material directly entrapped perfluoropropane, prepared with ultra-high drug loading of porphyrin / camptothecin - fluorouridine (Porphyrin /Camptothecin-Fluoroxyuridine, PCF) Microbubbles. The PCF microbubbles can be used as an ultrasound contrast agent to significantly enhance the effect of ultrasound imaging, and the use of contrast-enhanced imaging to trace the distribution of PCF microbubbles in the body. When the PCF microbubbles reach the tumor site, the PCF microbubbles are converted into PCF nanoparticles in situ by ultrasound-targeted microbubble blasting (UTMD), so that the camptothecin-fluorouridine chemotherapeutic drug and the porphyrin photosensitizer are in the tumor site. The enrichment is increased by more than 5 times, while enrichment in normal tissues is reduced. Because PCF nanoparticles have strong fluorescence luminescence function, fluorescence imaging can be used to guide laser to accurately irradiate tumor tissue, and accurate PDT can be implemented. The tumor growth inhibition rate can reach more than 90%, and there is no obvious side effects.
The method can achieve synergy between chemotherapy and photodynamic therapy, and multi-pronged anti-tumor, has the advantages of minimally invasive, safe and efficient. This new type of tumor combination therapy strategy can be used for the treatment of various cancers such as prostate cancer and breast cancer, and has a good clinical application prospect. The research results were published in the international nanotechnology top journal "ACS Nano".
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