Some researchers are working hard to find safer ways to deliver anticancer drugs to cancer cells without harming healthy cells, while others are working to stimulate the immune system against cancer; currently, research from the University of Pennsylvania Combining these two theories, they encapsulate the degradable polymer nanoparticles with anticancer drugs and inject them into immune cells to create an intelligent, targeted system to fight specific types of cancer cells. .
"The traditional way to fight cancer is to inject anticancer drugs into the nanotubes and then inject the nanoparticles into the blood vessels, because the particles are small, and if they reach the location of the cancer cells, they are likely to break through the walls of the blood vessels," the researchers said. "By wrapping some antibodies on the surface of nanoparticles, specific proteins or peptides can increase their interaction with cancer cells. However, this is still a passive delivery technology. If the nanoparticles do not go to cancer cells, then the cancer cells will touch. Less than drugs.
The research team hopes to find more effective drug delivery methods, regardless of where the cancer cells are, blood, brain, or other organs of the body. One group of researchers studied the immune system and cancer for ten years, while the other group is a biochemist who understands how to make nanoparticles degradable. They also understand how nanoparticles can attach proteins and peptides to their surfaces. They use fluorescent materials. So when the drug is being transported, the researchers can track its location. In addition, they also studied the microenvironment of cancer cells and found that there are multiple signs of inflammation around the cancer cells, just like the ones that appear when infected. .
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