Release date: 2016-02-22
Staining on the graph shows that after one week of culture, the arteries produce contractile proteins (left) and troponin (right), which allow the arteries to contract and relax, responding to external stimuli.
According to the latest news from Duke University, the school's engineers have developed a new technology for rapidly manufacturing artificial arteries, which is 10 times faster than tissue engineering to make blood vessels. The artificial artery can naturally produce the necessary maintenance for normal operation of the arteries. Biochemical signal.
The arterial wall has multiple layers of cells, the innermost cells are in the innermost part, interacting with blood circulation, and the interstitial layer is composed of smooth muscle cells, which help control blood flow and blood pressure. The two layers communicate through a set of chemical signals that control the vascular system's response to external stimuli such as drugs and physical exercise. The research team created an artificial artery containing two layers of cells and proved that the two layers can communicate and function normally.
Researchers in a related paper published in the Nature Science Report, the artificial blood vessel, is also a reduced 3D micro-artificial organ platform that can be used to test drug efficacy and side effects.
George Trasky, of the Department of Biomedical Engineering at Duke University's Pratt Institute of Engineering, said that most of the previous studies focused on mesocellular cells, and there were few studies on endothelial cells. No one can prove how these two layers are. Interactive. Many artificial tissue techniques are quite complex and time consuming, and it usually takes 6 to 8 weeks to grow an artery in the laboratory.
The team used a rapid method of generating trachea that puts the desired tissue cells into collagen, squeezes it for a few minutes, squeezes out excess water, and increases the mechanical strength of the growing tissue. They modified this method to create arteries, creating a small artery that is only one-tenth the size of a human common artery. Traski said that because of the smaller diameter, a large number of blood vessels can be used in a few hours.
The researchers then observed the response of the new artery to natural and anthropogenic stimuli, including testing whether statins inhibit inflammation, and whether chemical signals released by endothelial cells allow the interstitial cells to relax and contract. In both tests, the artificial arteries worked properly.
Traski said that they will next observe the impact of certain rare genetic diseases on the artery, and the ultimate goal is to complete the "drug screening tissue chip" program to create a more accurate and reliable drug testing system than animal models.
Source: Technology Daily
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