Recently, researchers from Purdue University have invented an ultra-sensitive biosensor that can detect early and timely biochemical reactions involved in cancer and patient personalized medication. This biosensor combines two different types of sensors that are hundreds of times more sensitive than typical sensors. According to researcher Muhammad A. Alam, in general, different types of biosensors have different detection sensitivities, but if they are combined, they will overcome their sensitivity limitations. Relevant research results were published in the international magazine PNAS on May 14.
The biosensor, called Flexure-FET, combines a mechanical sensor with an electronic sensor that recognizes the molecular weight and size of bioactive molecules. Electronic sensors can use electric charges to identify molecules. This new sensor can be charged. Detection with uncharged biomolecules is more extensive than typical sensors. Flexure-FET has two potential applications: 1. Individualized medicine that accurately records patient protein and DNA information and provides more accurate diagnostic and therapeutic recommendations; 2. Early detection of cancer and other diseases.
A new ultra-sensitive biosensor for early detection of biochemical reactions involving cancer and patient-specific medications
In early cancer diagnosis, Flexure-FET can perform the necessary detection of small amounts of DNA fragments and proteins in the pre-disease period before the disease is detected by other testing equipment. The mechanical part of the sensor is a vibrating cantilever (similar to a tiny diving board). Silicon wafer), under the cantilever is an electric wafer, which is the electronic part of the sensor. In other mechanical sensors, the laser can measure the vibration frequency and the skew of the cantilever, and it depends on the type of biomolecule. However, this new sensor uses only an electric wafer to measure the vibration frequency and the skew of the cantilever.
This new biosensor can maximize the detection sensitivity by adjusting the overall structure. The cantilever is pulled by the electric field, and the electric chip relies on the voltage to adjust its sensitivity. Researcher Alam says that you can use whatever you can Think of the molecules to detect, the sensor will give you the most accurate measurement results. A key innovation of this new technology is the elimination of the limitations of the reference electrode, whereas conventional biosensors require a reference electrode. Finally, the researchers said that the elimination of the reference electrode can make the biosensor more compact, and because of its low cost and practicality, it is more practical and feasible for the majority of doctors.
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