Release date: 2006-08-29
The future "nanotechnology" will appear in the field of health care
Although nanotechnology can produce a variety of products from non-stained fabrics to more acquainting and lighter tennis rackets in a groundbreaking manner, researchers believe that in the near future, the most significant impact of nanotechnology will emerge. Health care field.
Currently, researchers at the University of Chicago Medical Center in Chicago are working with Argonne National Laboratory and the Illinois Institute of Technology to look forward to using the most advanced nanotechnology to improve women's health. They believe that nanotechnology can provide people with new ways to diagnose and treat ovarian cancer.
Dr. Jacob Rothmenhe, director of the Department of Obstetrics and Gynecology, Los Angeles University, said: "In recent decades, many cancers have caused a significant decline in human mortality. But in the past 50 years, ovarian cancer has caused The mortality rate has not changed much. The main reason for this is the diagnosis delay. By understanding the unique properties of nanotechnology, we hope to obtain highly sensitive molecular imaging methods to detect ovarian cancer earlier and develop nanoscale. A drug transport that delivers the drug directly into the tumor cells."
Dr. Chen Liaohai, a molecular biologist and head of the nano-biological group at the Argonne National Laboratory, said that because early diagnosis of ovarian cancer requires detection and characterization of very small amounts of biomarkers, nanotechnology-based medicine is needed. means.
1 nanometer is one billionth of a meter, which is equivalent to one in eight thousand of human hair. Nano-scale machines can perform tasks unimaginable in other devices in the human body, such as its ability to enter human cells and move along the walls of blood vessels, making it easy to interact with individual molecules on the cell surface and inside the cell. At the same time, it does not change the behavior of these molecules.
There are three major researches in the application of nanotechnology to ovarian cancer medicine at Loch University.
One is to develop a cancer detection method that does not require umbilical biopsy. In collaboration with Dr. Wang Rong, an associate professor at the Illinois Institute of Technology, researchers at the Medical Center used a high-resolution microscope that analyzes the interaction between independent protein molecules—atomizing force microscopy to understand cancer cells and The molecular structure of normal cells and the hardness between them. Usually, the cancer tissue wall is harder than normal tissue, so the researchers hope to develop a probe to test the hardness of ovarian tissue to diagnose the presence of cancerous tissue.
The second is to use the nanotechnology to use the filter-type germ molecules as a template to produce a nano-developing probe and drug delivery tool with uniform specifications. The researchers plan to reject the DNA from the filter organism molecules and replace them with developers or drugs. After being transformed into a human body to adsorb cancer cells, the modified filter fungus molecules can inject a developer or a therapeutic drug into the cancer cells. The technology will help people develop early cancer diagnostics and cancer therapies that target cancer cells without destroying normal cells.
The third is to develop nano-scale contrast agents that use ultrasound to diagnose ovarian cancer. Nano-sized ultrasound imaging contrast agents are able to reach the tumor tissue through the finest capillaries. Under the action of ultrasound, they are able to illuminate, which may indicate early changes in arterial vessels due to malignant changes in the ovaries. If the study is successful, the researchers will immediately study directional development and targeted therapy.
In the United States, ovarian cancer is the fifth most common cancer in women, and the number of deaths per year exceeds the total number of deaths caused by all other gynecological diseases in North America. In addition, about 75% of patients are diagnosed with disease in the late stage of cancer. Currently, there is no effective means for medical treatment.
Rothmenhe also said: "In the past five years, nanotechnology has achieved great results, but it has not yet been applied to women's health. We believe that this 'microparticle' technology has a rapid detection that has never been seen before. The ability to make early cancer. This research will open up new avenues for drug development, diagnostic imaging and eventual prevention of disease."
Shanghai Medical Device Network
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