Under the support of the 863 Program, China's nano-biotechnology research focuses on three aspects: nano-medicine development technology, nano-detection, diagnosis and treatment technologies, and nano-biological devices.
(1) Developed a batch of biological nanodevices. A variety of biosensors have been developed by modifying sensitive reagents that respond to specific detection objects on nanoparticle materials and have been applied in the biomedical field, such as the use of ligand receptor binding principles for surface modification of fluorescent nanoparticles. Lactobionic acid ligand that can specifically recognize the receptors of liver cancer cells, selectively and specifically recognizes liver cancer cells; establishes a novel SARS virus nucleic acid probe based on biological nanotechnology, and establishes a method for using silicon shell nanoparticles on glass chips A new method for the detection of SARS virus genome fragments.
Developed a fluorescent magnetic cell-targeted multifunctional nano-biological device; invented a simple, safe, efficient, and inexpensive method for synthesizing nuclear/shell semiconductor fluorescent quantum dots; developed a series of excellent quantum dot products and novel nano-biological devices. .
(2) A single-molecule PCR amplification technique was initially established. A single-molecule PCR amplification technique was initially established, and when the copy number was less than 10, PCR amplification of DNA molecules was successfully achieved and a certain proportion of successful amplification could be achieved. Related articles were published on JACS.
(3) The industrialization of agricultural nanomaterials and fertilizers progressed smoothly. “Key Nanotechnology Fertilizers†was submitted to the National Development and Reform Commission’s industrialization project “Plant Nutrition Functional Slow/Controlled Release Materials Industrialization Demonstration Project†and it has been approved. At the same time, it has also cooperated with Tianjin Kanglong Agricultural Ecology Co., Ltd. to build a “nano†Material-bonded-encapsulated slow/controlled release material “Northern Industrialization Demonstration Base, with an annual output of 30,000 tons of agricultural nanomaterials and 50,000 tons/year slow/controlled release fertilizer, and the agricultural nanomaterials workshop has been in operation. Fertilizer workshop is being tested.
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