There is a new theoretical basis for the treatment of colorectal cancer

:2018-12-06

The international academic journal "Science" recently published the Peking University Third Hospital Fu Wei team, Qiao Jie team and Peking University School of Life Sciences Biodynamic Optical Imaging Center Tang Fuyue team research results of human colorectal cancer single-cell multi-study sequencing research .

For the first time in the world, this study has deeply analyzed the characteristics and interrelationships of genomic copy number variation, DNA methylation abnormality and gene expression changes during the occurrence and metastasis of human colorectal cancer from single cell resolution and multi-group level. The research on the mechanism of metastasis of colorectal cancer points out a new direction and provides a new theoretical basis for the clinical treatment of metastatic colorectal cancer.

Based on the comprehensive establishment of a single-cell tracking system for metastatic colorectal cancer, this study deeply studied the regulatory relationship between colorectal cancer genome, methylation group and transcriptome, and revealed the occurrence of colorectal cancer metastasis at the three-group level. Mechanisms, which lay the foundation for predicting drug resistance in colorectal cancer, guiding the targeting and immunotherapy of metastatic colorectal cancer, and developing new treatments for cancer. (Reporter Wang Junping)

Source: People's Daily

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