Even today, when it comes to major infectious diseases, many people will still avoid it. When I heard "AIDS", many people still have the first reaction. Is there still a rescue? The state has cancelled the hepatitis B project test in admissions and employment examinations, but it has been a matter of nearly a decade. In some people's memory thinking, hepatitis B patients are still being looked at by others.
In fact, since the discovery of AIDS in the 1980s, AIDS has experienced three stages of incurable, refractory and cocktail therapy; although it cannot be completely cured at present, it has become like diabetes and hypertension in the world. A controlled chronic disease.
Usually, AIDS is called functional cure in the industry, and hepatitis B is called clinical cure. The core goal is the same, that is, the virus can be obtained through a good clinical strategy on the premise that the virus reservoir cannot be completely eliminated. Effectively inhibit, the body's immune function is normal, no medication, no spread, the disease will not progress. This will be a great breakthrough in the history of major infectious diseases.
At present, Haishanshi is targeting the high-risk groups of AIDS. Through the advantages and means of Internet technology, the detection needs of high-risk groups and the treatment and health management needs of people living with HIV have been achieved.
In the vast market, accurate detection technology is the hard power
By the end of 2015, there were approximately 37 million HIV carriers worldwide, with an increase of 2.1 million new infections and 1.1 million deaths from HIV-related illnesses, of which 40% or more than 14 million were unaware of their infection status.
In order to meet the needs of patients, Haishan relies on the world's original "micro-precision detection technology" and multi-channel social medical resources, initially set up Haishan Time Mall in mid-2017, providing anonymous AIDS for Internet users in the mall. Self-inspection, disease science education, doctor transfer, and disease management services.
Haishanshi's “micro-precision detection technology†is based on the molecular diagnostic technology of the parent company Guangzhou Hailite Biotechnology Co., Ltd. This technology test supports a professional third-party testing platform - the first in China to be guided by the cure of major infectious diseases, and supported by the Dongguan Municipal Government and Jinan University.
Guide treatment, accurately screen target population, long-term safe follow-up, micro-precision detection, help clinical cure early
One of the difficulties in clinical practice is how to find more and more accurate patients who have been clinically cured, and really help them achieve clinical cure; how to get more attention to patients close to clinical cure, and to achieve clinical cure through good treatment; To achieve a good prognosis for patients who have been clinically cured, to predict, prevent possible recurrence risks, and to maintain a long-term, healthy life.
Haishanshi aims to guide the realization of clinical cure through micro-accurate virus database detection; vertical management of chronic diseases can provide the most personalized and optimal clinical cure for countless patients.
"The weeds must be rooted," as long as the grass roots are still there, and they can germinate, the poisonous grass will always grow. AIDS is good, hepatitis B is also good, are viral diseases, although various antiviral drugs can now suppress the virus very well, but as long as the virus database is still there, the virus will be copied again, so to achieve clinical cure Need to continue to observe the size of the virus database. In the course of treatment, the effective inhibition of the virus bank is manifested by a decrease in the number and a decrease in activity. When the amount of virus can no longer be detected, the observation of the virus database becomes a signpost for guiding treatment.
By detecting the virus pool, clinicians are better able to find people who have achieved clinical cure and find people close to clinical cures. Just as we look at the whole sea, not just the beach in front of us, the beautiful pearls will naturally be more excavated.
Early detection and early treatment help clinical cure
The success of typical cases provides a new way for clinicians and scientists to better discover and find treatments. For example, the world's first functional cure for AIDS, "Mississippi infants", received antiviral treatment 30 hours after birth, is also the world's first case of functional cure through antiviral therapy.
Therefore, follow-up South African babies and French babies have reported more that some of them have stopped taking drugs for 12 years without a virus rebound. The consensus within the industry is that early detection of early treatment will help achieve a functional cure.
The detection of HIV-1 DNA dried blood spots based on micro-precision technology by Haishan is made possible by the very early detection of AIDS. Compared with the traditional antibody test from 3 weeks to 3 months in the window period, the HIV-1 DNA virus library is the core marker of infection. The window period only takes 3-7 days. It is the shortest HIV detection technology in the international HIV testing window. .
At the same time, based on the stability of DNA, users can collect peripheral blood (fingertip blood) at home, and send it back to the professional medical laboratory to get accurate results. It is not only simple, convenient and fast, but also full of anonymity. privacy.
Therefore, Haishan not only can detect HIV infection at an early stage, but also help people who are worried about their infection, more convenient to test, and more definitely exclude infection.
According to the report of the Beijing Municipal Center for Disease Control and Prevention, as of the end of October 2017, a total of 1,202 samples of qualified dry blood spots were collected from the Internet + dry blood spot HIV nucleic acid anonymous transmission test. A total of 149 HIV positive patients were found, of which 18 cases were Positive nucleic acid detection and negative antibody detection indicated a very early infection, accounting for 12.08%. This test confirmed that dry blood spot nucleic acid is more effective in eliminating various false negatives.
It is the real health to eliminate the psychological burden of patients through timely and accurate testing. Long-term concerns can easily lead to sub-health status, and even reduce immunity, forming a "yin disease."
According to the recommendation of the US Centers for Disease Control and Prevention, all healthy people should have at least one AIDS test. After all, today's AIDS population is not a special group such as drug users and blood sellers, but through homosexual behavior and heterosexual behavior. Spread. Under the premise of easy and easy detection and full privacy protection, the Haishanshi platform is used to detect and protect oneself, and it is a complete concern.
Slow disease health management, a new vertical management model for major infectious diseases
At present, the market layout of Haishanshi is mainly parallel to the two legs of the online and offline. Offline, relying on strong expert resources and social medical resources, cooperate with many hospitals, CDCs and social welfare organizations across the country, online, from the assembly of potential users - Weibo KOL, WeChat V, Volunteer Alliance, Network Red Doctor and other triggerable traffic portals to absorb users, create an authoritative popular science platform, establish a live communication platform for doctors and patients and a popular science community to answer questions for doctors and answer questions for patients.
Once the user has the detection requirement, he only needs to place the order directly through the platform. The platform will send the self-service test package to the user. The test package mainly includes blood collection blood spot, blood collection needle, sterile cotton, band-aid and description. After the user takes the blood, The blood sample is returned to the platform in the same manner. Throughout the whole process, the platform can not only help users to collect blood without leaving the house, fully protect the privacy of users, and can also quickly issue cell numbers and viruses within 24 hours.
Once the number of viruses detected by the user is detected, the Haishan platform can provide follow-up services to the user by following the steps below:
Step 1: Proactively contact the user, inform the user in a reasonable way and ask if you need to provide a doctor transfer service.
Step 2: Recommend users to the local hospital for reasonable early treatment
Step 3: Regularly push relevant disease treatment and health management information
Step 4: Provide a social group of patients to facilitate follow-up treatment and improve compliance
Step 5: Enter, periodically analyze and remind the electronic medical record with the user's permission
Step 6: Continuous testing service for the user's treatment process, guiding the optimization of treatment
Step 7: After achieving clinical cure, continue long-term follow-up to prevent virus rebound
Step 8: Provide health advice related to nutrition, exercise, etc. according to the user's condition.
In the specific service, Haishan will encounter some special cases. These cases are difficult to obtain rapid diagnosis in general medical institutions, but they can be quickly confirmed through rapid detection and service of the platform. For example, there was a patient in a hospital in Southwest China who had a very serious fungal infection in the mouth and lungs. This type of condition can often only occur in AIDS patients with low immunity. The hospital used a traditional antibody test to detect that the patient was weakly positive. In this case, most doctors subjectively think that the patient is carrying HIV; but because it is weak, the hospital is uncertain, and the sea and the sea are good. After obtaining the blood sample of the patient after the platform contact, the DNA of the patient was not detected, so the hospital finally determined that the patient was not an AIDS patient, but a simple fungal infection.
Therefore, the hospital treated the patient with a simple fungal infection and confirmed that the patient did not become infected with HIV during follow-up. When the patient was successfully cured and discharged shortly after, he repeatedly thanked the doctor and said that he had mistakenly thought that he was infected with HIV. He was afraid that he would commit suicide. The doctor gave him a new life.
These cases not only provide strong data support for the national research projects that Haishan participated in, but also promote the construction of bridges between the doctors and the users, which is more beneficial to the user's own health data management.
Taking HIV testing as the market entry point, I will go up and down
Based on the “supbio micro-precision detection technologyâ€, Haishanshi takes the detection service as the core, and horizontally constructs the detection service of major chronic diseases such as chronic hepatitis B, tuberculosis and cancer with AIDS as the core; Expanded into the "online consultation + medical community + chronic disease management + health mall" four-in-one O2O integrated vertical chronic disease management platform.
The Haishan Time Platform currently covers more than 1 million people in the entire network, with more than 25,000 people serving. It is currently building an online consultation tool platform, which can provide HIV-1 DNA dry blood spots and whole blood quantitative testing services, chronic hepatitis B HBV. DNA, HBV pgRNA, HBV cccDNA testing services, and medical referrals, consultation and medical information, and research services based on two diseases.
In the future, Haishan will continue to pay attention to the management of chronic diseases of major infectious diseases, so that more people can eliminate infections, and the public will stay away from infections; let infected people get close to clinical cure and achieve clinical cure; through long-term continuous follow-up, patients will have A better prognosis, through professional doctor consultation, to the actual clinical solution. In the end, Haishan hopes that more people can benefit from clinical cure, and they can return to normal social and healthy life without taking medicine for life.
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