Discover precise control of genomic rearrangement methods

The Synthetic Biology Research Team led by Prof. Yuan Yingjin from Tianjin University published three research articles in the journal Nature Communication, and introduced a series of research results on precise control of genomic rearrangement technology. This achievement fills the technical gap in genomic structural variation, improves the productivity of cell factories, and accelerates the evolution of microbes and the discovery of biological knowledge. This is another major technological advancement in the process of “designing life, recreating life, and reshaping life” after artificially synthesizing yeast chromosomes to break the boundaries between non-living matter and living matter, opening up genome rearrangement in synthetic biology research. This new field of research.

In the field of life sciences, genetic variation is the source of biological evolution, and artificial construction techniques at the level of complex genomic structural variation are challenging. The research team of Tianjin University is aiming at this problem and researching the method of accurately controlling the genomic rearrangement, so that the microbe, the yeast, which is the research object, produces geometrically-grown genomic variation in a limited time, driving its rapid evolution. They also pioneered a variety of methods to make the mutated yeast strains have stable biological activity and as a cell factory to produce β-carotene with high efficiency.

Saccharomyces cerevisiae is a model eukaryotic single-celled organism in biological research. Professor Yuan Yingjin said: "Chemical synthetic yeast can help humans understand more fundamental biological problems on the one hand, and achieve rapid evolution through genomic rearrangement systems on the other hand, in medicine, energy, environment, agriculture, Strains that have important application potential in industries such as industry." (People's Network)

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