Recently, the research team of Professor MIT's Robert Langer published a new anti-cancer technology in the journal Nature Communications. The researchers found that by hanging nanoparticles on cancer cells like a kite, they can better promote cancer cell apoptosis through the combination of drugs.
Currently, conventional anti-cancer studies focus more on the genetic or biochemical properties of tumors. Professor Langer and others have focused their attention on the physical properties of tumors in recent years. For solid tumors, they can change their physical properties by increasing the hardness or changing the blood flow, so that the tumor itself grows better. Naturally, researchers began to think, if artificially transforming the physical properties of tumors, can it make cancer cells uncomfortable and help kill cancer cells?
â–²This research comes from the team of Professor Robert Langer of MIT Daniel (Source: MIT)
Under this line of thinking, researchers began to explore how different physical properties affect tumor cells. To better determine these effects, the researchers also administered a pilot drug, TRAIL. This drug is a type of tumor necrosis factor that binds to receptors on the surface of tumor cells and causes programmed cell death. In this way, researchers can calculate the proportion of cancer deaths, and they can know whether different physical properties have a tumor suppressor effect or a cancer-promoting effect.
â–² Several young scientists brought this new breakthrough (Source: MIT)
The experiment quickly gained results. After a preliminary screening, the researchers found that the shear forces of the fluid made the cancer cells more sensitive to TRAIL. "After providing fluid, more tumor cells will begin to die under the influence of TRAIL," said Dr. Mitchell, the lead author of the study.
Is there any way to make the shearing effect of the fluid more obvious? Researchers have gained inspiration from everyday life. We all let go of kites. When the kite flies into the sky, a wave of airflow can produce a noticeable sway in the hand. Researchers also want to use this feature to put a group of "small kites" on the surface of cancer cells, constantly pulling cancer cells and enhancing the fluid shearing effect on the surface of cancer cells.
â–² Researchers hang "small kites" on the surface of cancer cells (Source: "Nature Communications")
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