Thanks to the power of 3D printing technology, scientists at Rice University in the United States have recently made new progress in studying Ewing's sarcoma (a kind of bone cancer). By using a 3D printed porous imitation bone scaffold, they found the size of the hole. , shape, and density can affect the value of tumor cells. From this they judge that the real situation should be the same, because the real bones also have a porous structure.
The study was led by Antonios Mikos, a bioengineer at Rice University. At present, they have written the results into a paper published in the Journal of Biomaterials Science and Engineering of the American Chemical Society.
According to Mikos, this 3D printed imitation skeletal structure is made of polymer materials. The pores therein limit the flow of liquid and thereby exert the resulting shear stress on the tumor cells. By changing the structure of the stent as a whole and the structure of the pores, that is, the environment in which the liquid flows, they can change the magnitude of the shear stress. Therefore, they believe that this is of great significance for the study of extreme treatment of bone cancer.
"Our goal is to develop a tumor model that captures the complexity of tumors outside the body and can be used for drug testing, ultimately helping to develop drugs and lowering the associated costs." Mikos said: "In this area of ​​research, 3D printing The stent is more effective than a flat petri dish because it has a realistic bone structure that reflects closer to real cellular activity."
In the actual study, Mikos and his team first 3D printed three different hole sizes of 0.2 mm, 0.6 mm and 1 mm, and then implanted tumor cells into it. In order to simulate the real situation of tumors affected by fluids, they also used a syringe.
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