On the 8th, the reporter learned from the team of Professor Zheng Zhenyu of Hangzhou Normal University that the team found that the longevity gene Sirt6 plays an important role in the steady state maintenance of hematopoietic stem cells, and is important for delaying stem cell aging and preventing bone marrow failure diseases. It can be used as a bone marrow failure disease. The target of treatment.
It is known that there are four subtypes of acetylases in mammals, which function through the interaction of the same or different enzymes and enzyme substrates, and are widely involved in physiological regulation such as stress regulation, fatty acid oxidation, energy metabolism, etc., with age. It grows and gradually decreases, so it is closely related to diseases such as aging and aging. It has been found that promoting the expression of silencing information regulator (SIRT) gene can prolong the lifespan of lower organisms, but its specific mechanism of action in stem cell homeostasis is still unclear.
Qi Zhenyu said that this study has newly discovered a silencing factor-related enzyme (Sirtuin), a member of the fourth member of the protein family, SIRT6, which causes the activity of the wingless gene (Wnt) signaling pathway to be up-regulated, that is, the downstream gene is over-expressed, eventually leading to hematopoiesis. Depletion of stem cells, and the use of Wnt signaling pathway inhibitors can reverse the excessive proliferation and depletion of SIRT6 knockout hematopoietic stem cells.
At the same time, the study reveals for the first time that SIRT6 can regulate important pathways in stem cells and aging from the epigenetic level, providing new potential targets and ideas for the research and intervention of aging and stem cell-related diseases, as well as exploring longevity. The gene Sirt6 provides a new perspective in the study of the regulation of stem cell biological functions.
A recent study by the Zhen Zhenyu team also found an important molecule (Wip1) that regulates stem cell senescence and tissue regeneration through two aging-related signaling pathways. This important molecular phosphatase-mediated DNA damage response negative feedback regulation mechanism plays an important role in stem cell senescence and tissue regeneration.
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