Scientists from the Harvard University's Wyss Institute have developed a new technology that can detect the risk of thrombosis, which may be good news for patients with abnormal blood clotting and platelet function. The relevant research results are published in the international academic journal Nature Communication.
Researchers use a biophysical approach to simulate what might happen to blood in a patient's vascular network. This technology can now be tested with blood samples, and in the future it will be integrated into other extracorporeal devices through which the patient's blood flows to provide doctors with predictive capabilities to help prevent thrombosis or internal bleeding.
In this study, the research team developed a microfluidic device through which blood flows like a small network of blood vessels flowing through the body. With an automatic pressure sensor and a specialized set of algorithms, the data acquired by the device can be analyzed in real time to accurately predict when a particular blood sample will block the vascular network.
The hollow tube of the device mimics the pathological features of narrowing of small blood vessels. This pathological phenomenon can occur as a side effect of some disease treatment drugs or methods in patients, often causing hemodynamic changes, which may lead to serious Life-threatening thrombosis or internal bleeding. Therefore, for some high-risk patients, it is very important to quickly detect the patient's healthy hemostasis and prevent thrombosis.
Using this microfluidic device to simulate the hemodynamics of small blood vessels combined with the latest data analysis software, the researchers can quickly quantify the patient's hemostatic capacity and predict whether a blood sample or patient will form a thrombus.
In addition, the device's real-time monitoring capability allows for continuous acquisition of a patient's blood agglutination level, which can significantly reduce the toxic side effects of anticoagulant therapy compared to traditional once-a-day or two-time blood tests. The researchers also said the device was able to detect a rare bleeding disorder that was difficult to detect using traditional methods, and patients with the disease had abnormal platelet function.
In a large animal experiment conducted in the study, the researchers directly introduced blood from animal blood vessels into the microfluidic device to measure thrombus formation parameters over a period of time. Through this study, they accurately predicted the time to blood clots in blood samples, which is faster and more accurate than the current clinical methods.
This new technology developed in this study will bring significant significance to the prevention and treatment of cardiovascular diseases such as cerebral thrombosis.
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