Release date: 2015-06-10
In collaboration with researchers at the University of Aarhus, Denmark, the company found a mirror-symmetric DNA molecule that is not recognized by the immune system and is not broken down by enzymes and can survive in the body for a long time. This achievement opens up new avenues for the use of genetic technology to treat difficult diseases such as cancer.
Symmetry in nature plays an important role. Symmetry can be seen everywhere in the human and animal world, with two arms, two legs, two nostrils, two lungs, and a pretty symmetrical face. However, aside from the human body's appearance, in the microscopic material world that constitutes human genes, the phenomenon of symmetry seems to be less obvious. Nucleotides and amino acids are the basic elements that make up DNA, RNA and protein. Scientists want to know if DNA molecules are also mirror symmetrical, if anything.
After long-term research, researchers at NOXXON Pharmaceuticals in Berlin and Aarhus University in Denmark have discovered a new class of nucleic acid-like aptamers, which are single-stranded molecules that are part of DNA. Natural aptamers are composed of D-nucleotides, and the aptamers discovered by the researchers contain D-nucleotides and L-nucleotides. The L-nucleotide is identical in composition to the native D-nucleotide, the only difference being that the former is a symmetric mirror of the latter.
Researchers have long been studying how to effectively use aptamers to fight off diseases. However, aptamers are often quickly recognized by the body's immune system and rapidly degraded by specific enzymes as dangerous substances. However, this mirror aptamer is not recognized by the immune system, is not broken down by enzymes, and can survive in the body for a long time. Scientists can use this feature to treat diseases.
An example is that the mirror aptamer developed by NOXXON can inhibit the distribution of C5a in proteins in humans. C5a plays an important role in anti-infection and inflammation. When a person gets sick, C5a can bind to hypertrophic leukocytes, causing effective release of histamine. However, too much C5a distribution can cause serious complications in patients and can lead to serious infections. In addition, mouse experiments have shown that C5a also promotes tumor growth and also contributes to organ failure caused by pneumonia.
Dr. Fate of NOXXON, together with scientists from the Institute of Molecular Biology at the University of Aarhus, found a symmetric mirror molecule that binds to C5a and binds it to C5a on mast cells to suppress excessive histamine release and containment. Inflammation. “One of the challenges in research is that the computer program we use to analyze nucleotide structures is designed for D-nucleotides, and now we want to mirror the L-nucleosides of D-nucleotides,†said Fate. The acid design needs to be re-converted." Eventually they completed the conversion of the program and used X-rays to capture the binding of C5a to mast cells and the atomic structure of the mirror molecule bound to C5a. The results of this study show that perfect mirror molecules can be formed on natural DNA and RNA molecules.
Source: Technology Daily
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