Nature: Certain immune system cells play an important role in obesity
December 24, 2014 Source: Bio Valley Bioon.com
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];December 24, 2014 / Bio Valley BIOON / -- Early research suggests that certain immune system cells may play an important role in weight management. Scientists now know that immune cells may help mice fight obesity. The new findings are published in the journal Nature.
The researchers found that compared with leaner people, cellular ILC2s are less common in obese adult abdominal fat. More importantly, in mouse experiments, they found that ILC2s seem to stimulate "beige" fat cells, thereby improving Heat burning. From this point of view, these (ILC2) cells do not work properly in obesity.
David Artis, a researcher at Weill Cornell Medical College in New York City, said: It is unclear why or how this happens, but these are key questions for future research. He said that the ultimate hope is to develop new ways to solve obesity. In the past few years, researchers have struggled to understand how the immune system affects metabolism and weight management. This sounds surprising, because the immune system is primarily resistant to body infections, but it makes sense from an evolutionary point of view.
He explained that although the direct task of the immune system is to fight infection, it is conceivable that some components of the immune system have to evolve and evolve to "communicate" with the adipose tissue in order to change the body's metabolism. As you can imagine, the immune system "tells" that the body of fat tissue will face malnutrition and will also adapt the body to adversity.
Dr. Charles Billington pointed out that when people are injured or have an allergic reaction, the body often goes into "high metabolism" or accelerates the burning calories. But Billington said the study and other recent work show how the immune system affects metabolism and may have weight control. However, he also stressed that there are many unknown factors, there is some overlap between the immune system and metabolism, and we don't really understand it now.
ILC2s are a group of immune cells that help fight infections and work in allergies. Artis and colleagues want to know if these cells might have other effects. Researchers began to study abdominal fat in obese adults and normal weight adults. It turns out that obese people have less ILC2s in fat, just like experimental obese mice. The researchers then injected IL-7 into laboratory mice, which is an immune system protein. The researchers found that interleukin 33 treatment boosted ILC2s in mouse white fat, thereby increasing calorie burning.
White fat, Billington explains, storing extra calories, the body behaves like a beer belly or a swim ring. But there is another type of fat called brown fat that burns calories to produce heat. In addition to the white and brown varieties, there is a third type of body fat called so-called beige fat. Like brown fat, it burns calories to produce heat. More importantly, beige fat may play an important role in preventing obesity.
In his team experiments, ILC2 cells appear to enhance calorie burning by enhancing the storage of animal beige fat. Obviously, this research is in its infancy and there is still a lot of work to be done. But the goal is to develop new ways to treat obesity by better understanding the communication between the immune system and body fat. (Original link: http://news.bioon.com/article/6664026.html)
Inner Mongolia Hengxintonghui Supply Chain Management Services Co.,LTD , https://www.hxthfood.com