Release date: 2007-10-19
Mitochondrial DNA haplotypes and age-related macular degeneration Jones MM and colleagues at the University of Sydney, New South Wales, Australia, have investigated whether mitochondrial haplotypes are associated with age-related macular degeneration (ARM). Researchers evaluated the association between mitochondrial haplotypes and ARM in 3,509 residents over 49 years of age living in western Sydney. The researchers photographed the retina of the subject's eyes (1999-2001) and then graded the ARM according to the Wisconsin grading system. They also performed a genetic analysis of mitochondrial DNA haplotypes and assessed the association between these genetic markers and ARM risk factors. The results showed that after adjusting for age, gender, and smoking status, haplotype H was associated with any (early and late) ARM (odds ratio [OR]: 0.75; 95% confidence interval [CI]: 0.58-0.97), early ARM (OR: 0.75; 95% CI: 0.57-0.98) and large soft drusen (OR: 0.70; 95% CI: 0.56-0.89) were associated with a reduced prevalence. The haplotype J was associated with a higher prevalence of clear soft-glass membranes (OR: 1.80; 95% CI: 1.18-2.73). The haplotype U was associated with an increased prevalence of retinal pigment abnormalities (OR: 1.45; 95% CI: 1.11-1.91). Jones et al concluded that the correlation between different haplotypes and the prevalence of ARM or ARM lesions suggests that these haplotypes may be genetic markers that predict individual ARM susceptibility. ——Midi Medical Network
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